Open AccessCell Migration: Surface Curvature Differentially Regulates Stem Cell Migration and Differentiation via Altered Attachment Morphology and Nuclear Deformation (Adv. Sci. 2/2017)
Author(s) -
Werner Maike,
Blanquer Sébastien B. G.,
Haimi Suvi P.,
Korus Gabriela,
Dunlop John W. C.,
Duda Georg N.,
Grijpma Dirk. W.,
Petersen Ansgar
Publication year - 2017
Publication title -
advanced science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.388
H-Index - 100
ISSN - 2198-3844
DOI - 10.1002/advs.201770007
Subject(s) - curvature , microbiology and biotechnology , cell , mesenchymal stem cell , stem cell , morphology (biology) , chemistry , cell migration , biophysics , materials science , biology , geometry , biochemistry , mathematics , genetics
Mesenchymal stem cells, harvested from the bone marrow, alter their behavior depending on the local curvature of the 3D‐printed surfaces they are seeded upon, as described by Ansgar Petersen and co‐workers in article number 1600347. While concave surfaces promote stem cell migration, convex surfaces enhance cell specification into bone cells, a process driven by curvature‐dependent forces on the cell's nucleus.