Open AccessMutual Destruction of Deep Lung Tumor Tissues by Nanodrug‐Conjugated Stealth Mesenchymal Stem Cells
Author(s) -
Kim SangWoo,
Lee Yeon Kyung,
Hong Jeong Hee,
Park JunYoung,
Choi YoungAe,
Lee Dong Un,
Choi Jungil,
Sym Sun Jin,
Kim SangHyun,
Khang Dongwoo
Publication year - 2018
Publication title -
advanced science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.388
H-Index - 100
ISSN - 2198-3844
DOI - 10.1002/advs.201700860
Subject(s) - mesenchymal stem cell , lung cancer , cancer research , lung , medicine , bone marrow , drug delivery , cancer stem cell , cancer , targeted drug delivery , pathology , drug , chemistry , pharmacology , organic chemistry
Lung cancer is a highly malignant tumor, and targeted delivery of anti‐cancer drugs to deep lung tumor tissue remains a challenge in drug design. Here, it is demonstrated that bone marrow mesenchymal stem cells armed with nanodrugs are highly targeted and mutually destructive with malignant lung cancer cells and successfully eradicate lung tumors tissues. Using this approach, the current clinical dose of anti‐cancer drugs for the treatment of malignant lung tumors can be decreased by more than 100‐fold without triggering immunotoxicity.