Open AccessOxygen‐Evolving Mesoporous Organosilica Coated Prussian Blue Nanoplatform for Highly Efficient Photodynamic Therapy of Tumors
Author(s) -
Yang Zhen Lu,
Tian Wei,
Wang Qing,
Zhao Ying,
Zhang Yun Lei,
Tian Ying,
Tang Yu Xia,
Wang Shou Ju,
Liu Ying,
Ni Qian Qian,
Lu Guang Ming,
Teng Zhao Gang,
Zhang Long Jiang
Publication year - 2018
Publication title -
advanced science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.388
H-Index - 100
ISSN - 2198-3844
DOI - 10.1002/advs.201700847
Subject(s) - singlet oxygen , photodynamic therapy , reactive oxygen species , prussian blue , biocompatibility , hydrogen peroxide , chemistry , catalase , mesoporous material , tumor hypoxia , oxygen , in vivo , materials science , nanotechnology , oxidative stress , catalysis , radiation therapy , biochemistry , medicine , electrochemistry , organic chemistry , microbiology and biotechnology , electrode , biology
Oxygen (O 2 ) plays a critical role during photodynamic therapy (PDT), however, hypoxia is quite common in most solid tumors, which limits the PDT efficacy and promotes the tumor aggression. Here, a safe and multifunctional oxygen‐evolving nanoplatform is costructured to overcome this problem. It is composed of a prussian blue (PB) core and chlorin e6 (Ce6) anchored periodic mesoporous organosilica (PMO) shell (denoted as PB@PMO‐Ce6). In the highly integrated nanoplatform, the PB with catalase‐like activity can catalyze hydrogen peroxide to generate O 2 , and the Ce6 transform the O 2 to generate more reactive oxygen species (ROS) upon laser irradiation for PDT. This PB@PMO‐Ce6 nanoplatform presents well‐defined core–shell structure, uniform diameter (105 ± 12 nm), and high biocompatibility. This study confirms that the PB@PMO‐Ce6 nanoplatform can generate more ROS to enhance PDT than free Ce6 in cellular level ( p < 0.001). In vivo, the singlet oxygen sensor green staining, tumor volume of tumor‐bearing mice, and histopathological analysis demonstrate that this oxygen‐evolving nanoplatform can elevate singlet oxygen to effectively inhibit tumor growth without obvious damage to major organs. The preliminary results from this study indicate the potential of biocompatible PB@PMO‐Ce6 nanoplatform to elevate O 2 and ROS for improving PDT efficacy.