Open Access3D Printing of Lotus Root‐Like Biomimetic Materials for Cell Delivery and Tissue Regeneration
Author(s) -
Feng Chun,
Zhang Wenjie,
Deng Cuijun,
Li Guanglong,
Chang Jiang,
Zhang Zhiyuan,
Jiang Xinquan,
Wu Chengtie
Publication year - 2017
Publication title -
advanced science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.388
H-Index - 100
ISSN - 2198-3844
DOI - 10.1002/advs.201700401
Subject(s) - regeneration (biology) , materials science , lotus effect , biomedical engineering , angiogenesis , nanotechnology , 3d printing , bone tissue , microbiology and biotechnology , chemistry , biology , medicine , composite material , raw material , organic chemistry , cancer research
Biomimetic materials have drawn more and more attention in recent years. Regeneration of large bone defects is still a major clinical challenge. In addition, vascularization plays an important role in the process of large bone regeneration and microchannel structure can induce endothelial cells to form rudimentary vasculature. In recent years, 3D printing scaffolds are major materials for large bone defect repair. However, these traditional 3D scaffolds have low porosity and nonchannel structure, which impede angiogenesis and osteogenesis. In this study, inspired by the microstructure of natural plant lotus root, biomimetic materials with lotus root‐like structures are successfully prepared via a modified 3D printing strategy. Compared with traditional 3D materials, these biomimetic materials can significantly improve in vitro cell attachment and proliferation as well as promote in vivo osteogenesis, indicating potential application for cell delivery and bone regeneration.