Open AccessControllable Photodynamic Therapy Implemented by Regulating Singlet Oxygen Efficiency
Author(s) -
Wu Wenting,
Shao Xiaodong,
Zhao Jianzhang,
Wu Mingbo
Publication year - 2017
Publication title -
advanced science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.388
H-Index - 100
ISSN - 2198-3844
DOI - 10.1002/advs.201700113
Subject(s) - photodynamic therapy , singlet oxygen , förster resonance energy transfer , photochemistry , intramolecular force , fluorescence , chemistry , nanotechnology , oxygen , computer science , materials science , physics , optics , stereochemistry , organic chemistry
With singlet oxygen ( 1 O 2 ) as the active agent, photodynamic therapy (PDT) is a promising technique for the treatment of various tumors and cancers. But it is hampered by the poor selectivity of most traditional photosensitizers (PS). In this review, we present a summary of controllable PDT implemented by regulating singlet oxygen efficiency. Herein, various controllable PDT strategies based on different initiating conditions (such as pH, light, H 2 O 2 and so on) have been summarized and introduced. More importantly, the action mechanisms of controllable PDT strategies, such as photoinduced electron transfer (PET), fluorescence resonance energy transfer (FRET), intramolecular charge transfer (ICT) and some physical/chemical means (e.g. captivity and release), are described as a key point in the article. This review provide a general overview of designing novel PS or strategies for effective and controllable PDT.