Open AccessOxidative Stress: 1,5‐Diazacyclooctanes, as Exclusive Oxidative Polyamine Metabolites, Inhibit Amyloid‐ β (1‐40) Fibrillization (Adv. Sci. 10/2016)
Author(s) -
Tsutsui Ayumi,
Zako Tamotsu,
Bu Tong,
Yamaguchi Yoshiki,
Maeda Mizuo,
Tanaka Katsunori
Publication year - 2016
Publication title -
advanced science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.388
H-Index - 100
ISSN - 2198-3844
DOI - 10.1002/advs.201670055
Subject(s) - polyamine , acrolein , oxidative stress , cytotoxicity , amyloid (mycology) , chemistry , biochemistry , oxidative phosphorylation , microbiology and biotechnology , pharmacology , biology , in vitro , inorganic chemistry , catalysis
The level of expression of polyamines and a highly reactive and toxic acrolein, has been linked to the progression of certain neurodenerative diseases such as Alzheimer's disease. But now the story has become more complex. Katsunori Tanaka and co‐workers discover that 1,5‐diazacyclooctanes constitute a previously unrecognized but exclusive and biologically relevant class of products formed by the polyamines and acrolein through a formal [4+4] cycloaddition reaction, in article 1600082. When combined in this way, these products regulate various biological functions, such as inhibiting A β 40 fibrillation—a key pathological process in Alzheimer's disease—and significantly reducing cell cytotoxicity. These results suggest that polyamine/acrolein conjugates are involved in the neutralization and modulation of neuro‐degeneration process, and thus that polyamines and acroleins may have both harmful and beneficial effects in the body.