Open AccessSequential Double “Clicks” toward Structurally Well‐Defined Heterogeneous N ‐Glycoclusters: The Importance of Cluster Heterogeneity on Pattern Recognition In Vivo
Author(s) -
Latypova Liliya,
Sibgatullina Regina,
Ogura Akihiro,
Fujiki Katsumasa,
Khabibrakhmanova Alsu,
Tahara Tsuyoshi,
Nozaki Satoshi,
Urano Sayaka,
Tsubokura Kazuki,
Onoe Hirotaka,
Watanabe Yasuyoshi,
Kurbangalieva Almira,
Tanaka Katsunori
Publication year - 2017
Publication title -
advanced science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.388
H-Index - 100
ISSN - 2198-3844
DOI - 10.1002/advs.201600394
Subject(s) - glycan , in vivo , kinetics , chemistry , cluster (spacecraft) , molecule , biological system , computer science , biochemistry , biology , glycoprotein , organic chemistry , physics , programming language , microbiology and biotechnology , quantum mechanics
Structurally well‐defined heterogeneous N ‐glycoclusters are prepared on albumin via a double click procedure. The number of glycan molecules present, in addition to the spatial arrangement of glycans in the heterogeneous glycoclusters, plays an important role in the in vivo kinetics and organ‐selective accumulation through glycan pattern recognition mechanisms.