Open AccessAnti‐Metastatic and Anti‐Angiogenic Activities of Core–Shell SiO 2 @LDH Loaded with Etoposide in Non‐Small Cell Lung Cancer
Author(s) -
Zhu Yanjing,
Zhu Rongrong,
Wang Mei,
Wu Bin,
He Xiaolie,
Qian Yechang,
Wang Shilong
Publication year - 2016
Publication title -
advanced science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.388
H-Index - 100
ISSN - 2198-3844
DOI - 10.1002/advs.201600229
Subject(s) - metastasis , cancer research , cancer cell , chemistry , lung cancer , in vivo , biophysics , cell migration , cancer , in vitro , nanotechnology , materials science , medicine , biology , biochemistry , pathology , microbiology and biotechnology
Currently, nanoparticles have gained a great attention in the anti‐tumor research area. However, to date, studies on the anti‐metastasis action of core–shell SiO 2 @LDH (LDH: layered double hydroxide) nanoparticles remain untouched. Two emerging aspects considered are establishing research on the controlling delivery effect of SiO 2 @LDH combined with anti‐cancer medicine from a new perspective. The fine properties synthetic SiO 2 @LDH‐VP16 (VP16: etoposide) are practiced to exhibit the nanoparticle's suppression on migration and invasion of non‐small cell lung cancer (NSCLC). Both in vitro and in vivo inspection shows that SiO 2 @LDH can help VP16 better function as an anti‐metastasis agent. On the other hand, anti‐angiogenic efficiency, co‐localization, as well as western blot are investigated to explain the possible mechanism. A clear mergence of SiO 2 @LDH‐VP16 and cytomembrane/microtubule may be observed from co‐location images. Results offer evidence that SiO 2 @LDH‐VP16 plays positions on cytomembrane and microtubules. It efficiently inhibits metastasis on NSCLC by reducing vascularization, and eliciting depression of the PI3K‐AKT and FAK‐Paxillin signaling pathways. SiO 2 @LDH‐VP16, the overall particle morphology, and function on anti‐metastasis and anti‐angiogenic may be tuned to give new opportunities for novel strategies for cancer therapy.