Open AccessCD44v6‐Peptide Functionalized Nanoparticles Selectively Bind to Metastatic Cancer Cells
Author(s) -
Li Linxian,
Schmitt Mark,
MatzkeOgi Alexandra,
Wadhwani Parvesh,
OrianRousseau Veronique,
Levkin Pavel A.
Publication year - 2017
Publication title -
advanced science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.388
H-Index - 100
ISSN - 2198-3844
DOI - 10.1002/advs.201600202
Subject(s) - nanocarriers , du145 , pancreatic cancer , cancer research , peptide , drug delivery , small molecule , nanoparticle , chemistry , pancreatic tumor , targeted drug delivery , cancer , cancer cell , nanotechnology , materials science , biochemistry , medicine , lncap
CD44v6 peptide functionalized nanoparticles are fabricated in a facile and controllable way to selectively bind to CD44v6 positive tumor cells with highly efficient anticancer and antimetastatic properties. The reported modular synthesis and facile preparation makes this system highly potent for developing novel multifunctional nanocarriers for therapeutic and/or diagnostic anticancer applications.