Open Access1,5‐Diazacyclooctanes, as Exclusive Oxidative Polyamine Metabolites, Inhibit Amyloid‐ β (1‐40) Fibrillization
Author(s) -
Tsutsui Ayumi,
Zako Tamotsu,
Bu Tong,
Yamaguchi Yoshiki,
Maeda Mizuo,
Tanaka Katsunori
Publication year - 2016
Publication title -
advanced science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.388
H-Index - 100
ISSN - 2198-3844
DOI - 10.1002/advs.201600082
Subject(s) - polyamine , oxidative phosphorylation , amyloid (mycology) , chemistry , biochemistry , oxidative damage , oxidative stress , biophysics , biology , inorganic chemistry
Biologically relevant 1,5‐diazacyclooctanes derived from polyamines and acrolein, inhibit Aβ40 peptide fibrillization and significantly suppress cell cytotoxicity. Formal [4+4] cycloaddition reaction of imines is thus involved in modulating oxidative stress processes associated with neural diseases.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom