Open Access1,5‐Diazacyclooctanes, as Exclusive Oxidative Polyamine Metabolites, Inhibit Amyloid‐ β (1‐40) Fibrillization
Author(s) -
Tsutsui Ayumi,
Zako Tamotsu,
Bu Tong,
Yamaguchi Yoshiki,
Maeda Mizuo,
Tanaka Katsunori
Publication year - 2016
Publication title -
advanced science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.388
H-Index - 100
ISSN - 2198-3844
DOI - 10.1002/advs.201600082
Subject(s) - polyamine , oxidative phosphorylation , amyloid (mycology) , chemistry , biochemistry , oxidative damage , oxidative stress , biophysics , biology , inorganic chemistry
Biologically relevant 1,5‐diazacyclooctanes derived from polyamines and acrolein, inhibit Aβ40 peptide fibrillization and significantly suppress cell cytotoxicity. Formal [4+4] cycloaddition reaction of imines is thus involved in modulating oxidative stress processes associated with neural diseases.