Open AccessVirus‐Surface‐Mimicking Surface Clustering of AuNPs onto DNA‐Entrapped Polymeric Nanoparticle for Enhanced Cellular Internalization and Nanocluster‐Induced NIR Photothermal Therapy
Author(s) -
Jia HuiZhen,
Chen WeiHai,
Wang Xuli,
Lei Qi,
Yin WeiNa,
Wang Yan,
Zhuo RenXi,
Feng Jun,
Zhang XianZheng
Publication year - 2015
Publication title -
advanced science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.388
H-Index - 100
ISSN - 2198-3844
DOI - 10.1002/advs.201500108
Subject(s) - transfection , photothermal therapy , genetic enhancement , internalization , gene delivery , dna , nanotechnology , oncolytic virus , virus , herpes simplex virus , nanoparticle , gene , chemistry , biophysics , cell , materials science , biology , virology , biochemistry
Virus‐surface‐mimicking decoration of deoxyribonucleic acid (DNA)‐entrapped polymeric nanoparticle with AuNPs is demonstrated to lead to enhanced cellular uptake, improved gene transfection, and particularly efficient near‐infrared photothermal therapy that cannot be achieved by both of them separately. This hybrid nanosystem represents a novel paradigm of multipurpose organic–inorganic nanoplatform, especially for cancer treatments.