Open AccessPharmacokinetic evaluation of novel pH ‐sensitive poly(2‐methoxyethyl methacrylate‐co‐itaconic acid) microgels in rabbits
Author(s) -
Rashid Zermina,
Ranjha Nazar Mohammad,
Rashid Fareeha,
Razzaq Rabia
Publication year - 2018
Publication title -
advances in polymer technology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.523
H-Index - 44
eISSN - 1098-2329
pISSN - 0730-6679
DOI - 10.1002/adv.22164
Subject(s) - itaconic acid , pharmacokinetics , drug , drug delivery , methacrylate , materials science , pharmacology , bioavailability , nuclear chemistry , chemistry , polymer , nanotechnology , medicine , copolymer , composite material
Novel copolymeric microgels of 2‐methoxyethyl methacrylate and itaconic acid have been proposed for pH ‐responsive oral delivery of therapeutics. In vitro evaluation confirmed the potential of p( MEMA ‐co‐ IA ) microgels to protect the drug from harsh environment of stomach and to deliver drug in response to pH of the external environment over extended period of time. In the present study, p( MEMA ‐co‐ IA ) microgels have been evaluated for the pharmacokinetic parameters of model drug, esomeprazole in rabbits. Single‐dose noncompartmental study was conducted by oral administration of drug solution and drug‐loaded microgel. On comparison, it was found that the microgels have delayed the release of drug to about 2 hr, with decreased C max , prolonged t max , increased AUC 0− t , and prolonged MRT . The differences were statistically significant. In conclusion, p( MEMA ‐co‐ IA ) microgels have potential for preferential drug delivery into higher pH environment over prolonged period of time.