Open AccessIvabradine HCL ‐Loaded Polymeric Microspheres Consisting of Ethyl Cellulose and Eudragit FS 30D for Controlled Drug Release
Author(s) -
Majeed Abdul,
Ranjha Nazar Muhammad
Publication year - 2018
Publication title -
advances in polymer technology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.523
H-Index - 44
eISSN - 1098-2329
pISSN - 0730-6679
DOI - 10.1002/adv.21715
Subject(s) - differential scanning calorimetry , fourier transform infrared spectroscopy , materials science , ethyl cellulose , scanning electron microscope , nuclear chemistry , cellulose , diffusion , polymer , chemical engineering , chemistry , composite material , physics , engineering , thermodynamics
In this study, microspheres of Eudragit FS 30D and ethyl cellulose ( EC ) were prepared by oil‐in‐oil (O/O) solvent evaporation method with the addition of 1% span 80 as emulsifier. Ivabradine HC l ( IBH ) was encapsulated into microspheres by the in situ method. The resultant microspheres were characterized with respect to drug loading, Fourier transform infrared spectroscopy ( FTIR ), scanning electron microscopy ( SEM ), X‐ray diffractometry ( XRD ), differential scanning calorimetry ( DSC ), and release behavior. Chemical stability of IBH encapsulated into prepared microspheres was confirmed by FTIR , DSC , and XRD analysis. SEM images showed spherical microspheres. Maximum percentage entrapment efficiency of ivabradine was found to be 45.1% and percentage yield was about 71.66%. Maximum in vitro drug release was 95.9% for the pH 7.5 buffer solution which demonstrated the pH sensitivity of microspheres. Cumulative drug release data were analyzed using different kinetic models. Korsmeyer–Peppas equation was used to determine the value of n which follows non‐Fickian diffusion.