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Modeling of Deformable Cell Separation in a Microchannel with Sequenced Pillars (Adv. Theory Simul. 9/2021)
Author(s) -
Hymel Scott J.,
Fujioka Hideki,
Khismatullin Damir B.
Publication year - 2021
Publication title -
advanced theory and simulations
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.068
H-Index - 17
ISSN - 2513-0390
DOI - 10.1002/adts.202170020
Subject(s) - microchannel , microfluidics , separation (statistics) , pillar , cell , channel (broadcasting) , red blood cell , inlet , materials science , circulating tumor cell , nanotechnology , mechanics , chemistry , computer science , physics , biology , engineering , mechanical engineering , telecommunications , biochemistry , cancer , machine learning , genetics , metastasis
Modeling Cell Separation in a Microchannel In article number 2100086, Damir Khismatullin and co‐workers identify multi‐pillar configurations that can increase the efficiency of microfluidic separation of deformable cells by ≈1300% using numerical algorithms for cell migration. Separation of circulating tumor cells (red) and white blood cells (blue) in a microfluidic channel with three widely spaced columns is shown. The pillars disrupt the velocity field (inlet), altering the direction of the cells and increasing the cell‐to‐cell distance.