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Photosensitizer‐Free Phototherapy with Peptide Micelle Nanoadjuvants for Cancer Vaccine against Metastasis of Melanoma (Adv. Therap. 8/2021)
Author(s) -
Le QuocViet,
Kim Dongyoon,
Lee Jaiwoo,
Shim Gayong,
Oh YuKyoung
Publication year - 2021
Publication title -
advanced therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.125
0ISSN - 2366-3987
DOI - 10.1002/adtp.202170018
Subject(s) - photosensitizer , cancer research , peptide , micelle , chemistry , melanoma , imiquimod , metastasis , photothermal therapy , medicine , cancer , dermatology , materials science , photochemistry , nanotechnology , biochemistry , aqueous solution
Photosensitizer‐free vaccination strategy can be accompanied by delivery of nanoadjuvants. B16F10 melanoma cells show a photothermal effect under irradiation of near‐infrared light. The nanoadjuvant, with imiquimod in amphiphilic peptide‐based micelles, induces dendritic cell maturation. Near‐infrared‐irradiated and nanoadjuvant‐treated group prevents lung metastasis of B16F10. Photosensitizer‐free phototherapy with a peptide micelle nanoadjuvant has potential for clinical translation as a melanoma vaccine. This is reported by Gayong Shim, Yu‐Kyoung Oh, and co‐workes in article number 2000288.