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Ultrasound Triggered Co‐Delivery of Therapeutic MicroRNAs and a Triple Suicide Gene Therapy Vector by Using Biocompatible Polymer Nanoparticles for Improved Cancer Therapy in Mouse Models (Adv. Therap. 5/2021)
Author(s) -
Kumar Sukumar Uday,
Wang Huaijun,
Telichko Arsenii V.,
Natarajan Arutselvan,
Bettinger Thierry,
Cherkaoui Samir,
Massoud Tarik F.,
Dahl Jeremy J.,
Paulmurugan Ramasamy
Publication year - 2021
Publication title -
advanced therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.125
0ISSN - 2366-3987
DOI - 10.1002/adtp.202170009
Subject(s) - nanomedicine , genetic enhancement , cancer research , microrna , gene delivery , suicide gene , medicine , cancer , cancer therapy , nanoparticle , nanotechnology , materials science , gene , chemistry , biochemistry
A simple and noninvasive targeted delivery of nanomaterials can drive new advancements in cancer nanomedicine. In article number 2000197, Ramasamy Paulmurugan and co‐workers in collaboration with Bracco Suisse SA have demonstrated ultrasound assisted targeted delivery of therapeutic microRNAs and triple therapeutic genes loaded PLGA‐PEG‐PEI nanoparticles to HCC and TNBC tumors in immunocompetent syngeneic mouse models for effective cancer gene therapy.