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Hepatocellular Carcinoma: Acoustically Driven Microbubbles Enable Targeted Delivery of microRNA‐Loaded Nanoparticles to Spontaneous Hepatocellular Neoplasia in Canines (Adv. Therap. 12/2020)
Author(s) -
Kumar Sukumar Uday,
Telichko Arsenii V.,
Wang Huaijun,
Hyun Dongwoon,
Johnson Eric G.,
Kent Michael S.,
Rebhun Robert B.,
Dahl Jeremy J.,
Culp William T. N.,
Paulmurugan Ramasamy
Publication year - 2020
Publication title -
advanced therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.125
0ISSN - 2366-3987
DOI - 10.1002/adtp.202070027
Subject(s) - hepatocellular carcinoma , microbubbles , microrna , medicine , cancer research , oncology , ultrasound , radiology , biology , gene , genetics
In article number 2000120, Jeremy J. Dahl, William T. N. Culp, Ramasamy Paulmurugan and co‐workers demonstrate a promising outcome from ultrasound assisted targeted delivery of therapeutic microRNAs loaded nanoparticles to spontaneous hepatocellular carcinoma in canines. This study lays the foundation for the safety and efficacy of this approach and the findings warrant a smooth transition to clinical trials.