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Drug Delivery: Surfactant‐Stripped Cabazitaxel Micelles Stabilized by Clotrimazole or Mifepristone (Adv. Therap. 3/2020)
Author(s) -
Sun Boyang,
Chitgupi Upendra,
Li Changning,
Federizon Jasmin,
Zhang Changjie,
Ruszaj Donna M.,
Razi Aida,
Ortega Joaquin,
Neelamegham Sriram,
Zhang Yumiao,
Lovell Jonathan F
Publication year - 2020
Publication title -
advanced therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.125
0ISSN - 2366-3987
DOI - 10.1002/adtp.202070007
Subject(s) - cabazitaxel , pulmonary surfactant , micelle , drug , chemistry , drug delivery , pharmacology , chromatography , combinatorial chemistry , organic chemistry , medicine , cancer , prostate cancer , androgen deprivation therapy , biochemistry , aqueous solution
The cover image representing article number 1900161 by Jonathan F Lovell and co‐workers shows aggregates formed by the anti‐cancer drug cabazitaxel. In this work, it is shown that by co‐formulating cabazitaxel in unique surfactant micelles with certain other hydrophobic cargo, aggregation can be prevented, resulting in a potent chemotherapy formulation with long‐term liquid storage stability and a high drug‐to‐excipient ratio.