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Antisense Oligonucleotides: A 50‐nm‐Sized Micellar Assembly of Thermoresponsive Polymer‐Antisense Oligonucleotide Conjugates for Enhanced Gene Knockdown in Lung Cancer by Intratracheal Administration (Adv. Therap. 2/2020)
Author(s) -
Kim Beob Soo,
Osawa Shigehito,
Naito Mitsuru,
Ogura Satomi,
Kamegawa Rimpei,
Ishida Hiroki,
Kim Hyun Jin,
Uchida Satoshi,
Miyata Kanjiro
Publication year - 2020
Publication title -
advanced therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.125
0ISSN - 2366-3987
DOI - 10.1002/adtp.202070003
Subject(s) - gene knockdown , oligonucleotide , conjugate , polymer , lung cancer , chemistry , microbiology and biotechnology , gene , materials science , biology , medicine , biochemistry , organic chemistry , pathology , mathematical analysis , mathematics
In article number 1900123, Kanjiro Miyata and co‐workers develop a micellar assembly (ASOball) from a covalent conjugation between a thermoresponsive polymer, poly(2‐n‐propyl‐2‐oxazoline), and antisense oligonucleotide (ASO). The ASOball exhibits prolonged retention of ASO payloads in the lung and an orthotopic lung cancer model tissue, resulting in a superior gene knockdown effect in the lung cancer.