Antisense Oligonucleotides: A 50‐nm‐Sized Micellar Assembly of Thermoresponsive Polymer‐Antisense Oligonucleotide Conjugates for Enhanced Gene Knockdown in Lung Cancer by Intratracheal Administration (Adv. Therap. 2/2020) | Zendy

Kim Beob Soo | Zendy; Osawa Shigehito | Zendy; Naito Mitsuru | Zendy; Ogura Satomi | Zendy; Kamegawa Rimpei | Zendy; Ishida Hiroki | Zendy; Kim Hyun Jin | Zendy; Uchida Satoshi | Zendy; Miyata Kanjiro | Zendy

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Antisense Oligonucleotides: A 50‐nm‐Sized Micellar Assembly of Thermoresponsive Polymer‐Antisense Oligonucleotide Conjugates for Enhanced Gene Knockdown in Lung Cancer by Intratracheal Administration (Adv. Therap. 2/2020)

Author(s) -

Kim Beob Soo,

Osawa Shigehito,

Naito Mitsuru,

Ogura Satomi,

Kamegawa Rimpei,

Ishida Hiroki,

Kim Hyun Jin,

Uchida Satoshi,

Miyata Kanjiro

Publication year - 2020

Publication title -

advanced therapeutics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.125

0

ISSN - 2366-3987

DOI - 10.1002/adtp.202070003

Subject(s) - gene knockdown , oligonucleotide , conjugate , polymer , lung cancer , chemistry , microbiology and biotechnology , gene , materials science , biology , medicine , biochemistry , organic chemistry , pathology , mathematical analysis , mathematics

In article number 1900123, Kanjiro Miyata and co‐workers develop a micellar assembly (ASOball) from a covalent conjugation between a thermoresponsive polymer, poly(2‐n‐propyl‐2‐oxazoline), and antisense oligonucleotide (ASO). The ASOball exhibits prolonged retention of ASO payloads in the lung and an orthotopic lung cancer model tissue, resulting in a superior gene knockdown effect in the lung cancer.

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