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Recombinant Human Epidermal Growth Factor/Quatsome Nanoconjugates: A Robust Topical Delivery System for Complex Wound Healing
Author(s) -
FerrerTasies Lidia,
Santana Hector,
CabreraPuig Ingrid,
GonzálezMira Elisabet,
BallellHosa Lídia,
CastellarÁlvarez Carla,
Córdoba Alba,
MerloMas Josep,
Gerónimo Haydee,
Chinea Glay,
Falcón Viviana,
MorenoCalvo Evelyn,
Pedersen Jan Skov,
Romero Jessica,
NavarroRequena Claudia,
Valdés Calixto,
Limonta Miladys,
Berlanga Jorge,
Sala Santiago,
Martínez Eduardo,
Veciana Jaume,
Ventosa Nora
Publication year - 2021
Publication title -
advanced therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.125
0ISSN - 2366-3987
DOI - 10.1002/adtp.202000260
Subject(s) - biodistribution , nanomedicine , drug delivery , wound healing , nanotechnology , materials science , drug , biomedical engineering , pharmacology , nanoparticle , chemistry , medicine , immunology , biochemistry , in vitro
A multitude of microparticles and nanoparticles is developed to improve the delivery of different small drugs and large biomolecules, which are subject to several hindering biological barriers that limit their optimal biodistribution and therapeutic effects. Here, a soft, reliable, and scalable method based on compressed CO 2 is reported for obtaining nanoconjugates of recombinant human epidermal growth factor and nanovesicles called quatsomes, where the latter consists of cholesterol and cetyltrimethylammonium bromide. These nanoconjugates exhibit appropriate values of the major critical quality attributes of colloidal nanomedicines, such as controlled and narrow nanoscopic particle size distribution (which play important roles in determining their stability), drug loading, drug release, drug protection, targeting ability, and bioactivity. Also, they exhibit a dual action by 1) inbuilt antimicrobial activity preventing infections and 2) promoting regeneration of granulation tissue and re‐epithelialization with complete closure of complex wounds. Therefore, such nanoconjugates are a potential nanomedicine for the topical treatment of complex wounds, particularly diabetic foot ulcers and venous leg ulcers.