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Engineered Microneedle Patches for Controlled Release of Active Compounds: Recent Advances in Release Profile Tuning
Author(s) -
Jamaledin Rezvan,
Makvandi Pooyan,
Yiu Cynthia K. Y.,
Agarwal Tarun,
Vecchione Raffaele,
Sun Wujin,
Maiti Tapas Kumar,
Tay Franklin R.,
Netti Paolo Antonio
Publication year - 2020
Publication title -
advanced therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.125
0ISSN - 2366-3987
DOI - 10.1002/adtp.202000171
Subject(s) - transdermal , drug delivery , controlled release , drug , nanotechnology , pharmacology , biomedical engineering , medicine , materials science
Transdermal microneedle patches have attracted significant attention in the medical arena over the last decade as alternatives to traditional drug delivery methods. Microneedle patches are capable of delivering their payloads using burst‐ and sustained‐release mechanisms, or in response to internal/external triggers, to optimize their therapeutic potency. Herein, drug release mechanisms and profiles are reviewed, along with the impact of the cargo release on cytotoxicity and delivery efficacy. The potential applications of microneedles in transdermal treatment, from prophylaxis to therapeutics, are also highlighted.