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Nanomedicine Revisited: Next Generation Therapies for Brain Cancer
Author(s) -
Bhargav Adip G.,
Mondal Sujan K.,
Garcia Cesar A.,
Green Jordan J.,
QuiñonesHinojosa Alfredo
Publication year - 2020
Publication title -
advanced therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.125
0ISSN - 2366-3987
DOI - 10.1002/adtp.202000118
Subject(s) - nanomedicine , medicine , brain cancer , cancer , radiation therapy , brain tumor , modalities , glioblastoma , immunotherapy , immune system , cancer treatment , neuroscience , bioinformatics , oncology , cancer research , pathology , nanotechnology , immunology , psychology , biology , social science , materials science , sociology , nanoparticle
Abstract Brain cancer persists as a difficult‐to‐treat condition. In particular, metastatic brain cancer and malignant primary brain tumors such as glioblastoma (GBM) are among the most deadly and still carry a dismal prognosis despite current standard of care with surgery and chemo‐radiation. Recent advances in nanotechnology have led to innovative nanomedicine strategies for the treatment of brain cancers and specifically for GBM. These strategies represent promising alternative or adjunctive therapies for conventional treatment modalities and are increasingly designed to target specific cell types such as brain tumor‐initiating cells and immune cells. This review provides an update on emerging insights into these nanomedicine strategies with a focus on nanoparticles as tools that facilitate 1) drug delivery 2) gene therapy, and 3) engineered‐cellular therapy for GBM and future directions for brain cancer treatment.