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Prussian Blue@Polyacrylic Acid/Au Aggregate Janus Nanoparticles for CT Imaging‐guided Chemotherapy and Enhanced Photothermal Therapy
Author(s) -
Li Dan,
Bao Aomin,
Chen Xiangjun,
Li Shengnan,
Wang Tingting,
Zhang Lingyu,
Ji Jingyu,
Li Qianqian,
Wang Chungang,
Gao Yuzhou,
Yang Ying,
Dong Xiangting
Publication year - 2020
Publication title -
advanced therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.125
0ISSN - 2366-3987
DOI - 10.1002/adtp.202000091
Subject(s) - photothermal therapy , prussian blue , polyacrylic acid , materials science , doxorubicin , nanoparticle , janus , nanotechnology , chemotherapy , chemistry , medicine , composite material , electrode , surgery , polymer , electrochemistry
Janus nanoparticles (JNPs) have been widely researched for numerous biomedical applications. However, few studies have integrated enhanced photothermal therapy, effective chemotherapy, and diagnostic imaging in a single nanoplatform. Here, unique Prussian blue@polyacrylic acid/Au aggregate JNPs (PB@PAA/Au‐A JNPs) are prepared by a facile and mild method. The exposed surfaces in the JNPs maintain and utilize the original photothermal properties of the PB and Au domains. A heterostructure also adds the functionality of drug loading, which cannot be realized in a common core–shell structure. Notably, the coupling effect of two distinct PB and Au‐A domains leads to a superior photothermal conversion efficiency ( η ) of 49.4%, which is 9.9% higher than that of PB NPs. Synthesized doxorubicin‐loaded PB@PAA/Au‐A JNPs (DOX‐loaded PB@PAA/Au‐A JNPs) can be applied to computed tomography imaging‐guided chemotherapy and enhanced photothermal therapy, collectively promoting tumor inhibition.