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Maltotriose Conjugated Metal–Organic Frameworks for Selective Targeting and Photodynamic Therapy of Triple Negative Breast Cancer Cells and Tumor Associated Macrophages
Author(s) -
Sakamaki Yoshie,
Ozdemir John,
Diaz Perez Alda,
Heidrick Zachary,
Watson Olivia,
Tsuji Miu,
Salmon Christopher,
BattaMpouma Joseph,
Azzun Anthony,
Lomonte Valerie,
Du Yuchun,
Stenken Julie,
Kim JinWoo,
Beyzavi M. Hassan
Publication year - 2020
Publication title -
advanced therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.125
0ISSN - 2366-3987
DOI - 10.1002/adtp.202000029
Subject(s) - conjugated system , photodynamic therapy , cancer , breast cancer , drug delivery , ligand (biochemistry) , cancer research , cancer cell , nanotechnology , materials science , chemistry , medicine , receptor , organic chemistry , polymer
Metal–organic frameworks (MOFs) are a well‐suited platform for drug delivery systems that can affect photodynamic therapy (PDT). A well‐designed PDT delivery system to treat cancer can overcome some problems of current PDT such as prolonged photosensitivity and tumor specificity. Triple negative breast cancer (TNBC) is difficult to treat with existing chemotherapy and often requires surgery because it quickly metastasizes throughout the body. Tumor associated macrophages (TAM) are known to be M2‐like macrophages, which are involved in processes of cancer progression, such as angiogenesis, matrix remodeling, and metastases. These roles are brought on by the expression of the CD206 (mannose receptor) on the surface of the macrophage. MOF nanoparticles around 50 nm are synthesized by a solvothermal reaction of Mn(III)‐tetrakis(4‐carboxyphenyl) porphyrin, tetrakis(4‐carboxyphenyl) porphyrin, and ZrOCl 2 . Through postsynthetic modification, Zn(II) is incorporated into the tetrakis(4‐carboxyphenyl) porphyrin sites and potassium maltotrionate is conjugated with the empty coordination sites on the Zr 6 O 4 (OH) 4 clusters. The resultant maltotriose‐PCN‐224‐0.1Mn/0.9Zn is able to specifically target tumor cells and TAM. Upon irradiation by a light‐emitting diode (LED) source, TNBC and the TAM cells were selectively targeted by MA‐PCN‐224‐0.1Mn/0.9Zn via the glucose transporter (GLUT) and CD206 receptors. The MA‐PCN‐224‐0.1Mn/0.9Zn shows no toxicity toward normal cell lines and no dark toxicity.