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Antimicrobial Polypeptides: Molecular Architecture and Charging Effects Enhance the In Vitro and In Vivo Performance of Multi‐Arm Antimicrobial Agents Based on Star‐Shaped Poly( l ‐lysine) (Adv. Therap. 12/2019)
Author(s) -
Lu Chao,
Quan Guilan,
Su Ma,
Nimmagadda Alekhya,
Chen Weidong,
Pan Miao,
Teng Peng,
Yu Feiyuan,
Liu Xi,
Jiang Ling,
Du Wenyi,
Hu Wei,
Yao Fen,
Pan Xin,
Wu Chuanbin,
Liu Daojun,
Cai Jianfeng
Publication year - 2019
Publication title -
advanced therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.125
0ISSN - 2366-3987
DOI - 10.1002/adtp.201970025
Subject(s) - antimicrobial , in vivo , in vitro , lysine , membrane , cationic polymerization , chemistry , antimicrobial peptides , combinatorial chemistry , biophysics , biochemistry , biology , amino acid , polymer chemistry , organic chemistry , microbiology and biotechnology
In article 1900147, Chuanbin Wu, Daojun Liu, Jianfeng Cai and co‐workers design star‐shaped poly( l ‐lysine)s as a class of versatile molecular scaffolds for the development of multi‐arm antimicrobial agents. The star‐shaped molecular architecture of poly( l ‐lysine)s is characterized by unique advantages such as enhanced cationic charging density and improved proteolytic stability, thus exhibiting high membrane binding, effective membrane‐disruption and unprecedented antimicrobial activity in vitro and in vivo.