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Personalized Therapy: An NIR‐Fluorophore‐Based Inhibitor of SOD1 Induces Apoptosis by Targeting Transcription Cofactor PC4 (Adv. Therap. 5/2019)
Author(s) -
Luo Peng,
Tan Xu,
Luo Shenglin,
Wang Ziwen,
Long Lei,
Wang Yawei,
Liao Fengying,
Chen Long,
Zhang Chi,
He Jintao,
Huang Yinghui,
Liu Zujuan,
Gan Yibo,
Chen Zelin,
Wang Yang,
Liu Yunsheng,
Wang Yu,
Shi Chunmeng
Publication year - 2019
Publication title -
advanced therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.125
0ISSN - 2366-3987
DOI - 10.1002/adtp.201970009
Subject(s) - fluorophore , cancer research , colorectal cancer , cofactor , chemistry , transcription factor , apoptosis , transcription (linguistics) , medicine , cancer , biochemistry , fluorescence , enzyme , gene , physics , linguistics , philosophy , quantum mechanics
In article number adtp.201800148, Chunmeng Shi and co‐workers identify an NIR‐fluorophore‐based SOD1 inhibitor for colorectal cancer. With intrinsic structure‐inherent tumour‐targeting properties, the fluorophore significantly inhibits SOD1 expression and triggers ROS‐mediated cell death by transcription cofactor PC4, a novel potential therapeutic target and prognostic marker in colorectal cancer. This work may provide a promising candidate agent for personalized tumour‐targeted therapy and imaging.