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Epigenetic Therapies in the Precision Medicine Era
Author(s) -
Leite Michel Lopes,
Oliveira Kamila Botelho Sampaio,
Cunha Victor Albuquerque,
Dias Simoni Campos,
da Cunha Nicolau Brito,
Costa Fabricio F.
Publication year - 2020
Publication title -
advanced therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.125
0ISSN - 2366-3987
DOI - 10.1002/adtp.201900184
Subject(s) - epigenetics , epigenomics , dna methylation , computational biology , biology , histone , personalized medicine , precision medicine , biomedicine , dna sequencing , genetics , bioinformatics , dna , gene , gene expression
Abstract The elucidation of the 3D structure of DNA revolutionized modern science and created the basis for the field of molecular biology. The advent of DNA sequencing, and further refinement with Next‐Generation Sequencing (NGS) techniques, has made possible the enormous accumulation of data, which are useful for understanding the molecular mechanisms associated to various complex and rare diseases. Thanks to these advances, today it is known that several mechanisms regulate gene expression without the occurrence of mutations in the genome, a phenomenom known as Epigenetics and Epigenomics. The main mechanisms involved are DNA methylation, histone modifications, and non‐coding RNA transcription. The knowledge of these mechanisms applied to biomedicine has enabled the emergence of several fields, especially precision medicine, which is based on the genetic and epigenetic profiles of patients applied to personalized diagnostics and treatments. In this review, the history of the scientific advances that have enabled the development of precision medicine will be discussed, with a focus in epigenetics. Moreover, several molecules that have been approved for use or have the potential in epigenetic therapies (epidrugs) will also be discussed here, those of which act on targets responsible for maintaining the correct epigenetic pattern or correcting wrong patterns in diseases.