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Phenotypic Response and Personalized Medicine in Liver Cancer and Transplantation: Approaches to Complex Systems
Author(s) -
Zarrinpar Ali,
Kim Un Bi,
Boominathan Vijay
Publication year - 2020
Publication title -
advanced therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.125
0ISSN - 2366-3987
DOI - 10.1002/adtp.201900167
Subject(s) - personalized medicine , precision medicine , liver transplantation , medicine , liver cancer , transplantation , disease , biomarker discovery , bioinformatics , liver disease , biomarker , computational biology , cancer , data science , biology , computer science , pathology , genetics , gene , proteomics
Rapid improvements in medical technology, big data analysis, and molecular medicine come with promises of revolutionizing medical care. They span the spectrum from diagnostics to genome‐based drug selection to multi‐biomarker analysis to deciphering large amounts of data. Below, recent developments in personalized and precision medicine are reviewed, focusing specifically on the liver, ranging from fatty liver disease to liver cancer treatment and liver transplantation. Furthermore, current technologies and their advantages and limitations are discussed, in addition to ways in which these disadvantages can be overcome, using phenotypic personalized medicine.