Premium
Coating‐Sheddable CD44‐Targeted Poly( d , l ‐lactide‐ co ‐glycolide) Nanomedicines Fabricated by Using Photoclick‐Crosslinkable Surfactant
Author(s) -
Li Shuai,
Qiu Min,
Guo Jiakun,
Zhao Xiaofei,
Zhong Zhiyuan,
Deng Chao
Publication year - 2020
Publication title -
advanced therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.125
0ISSN - 2366-3987
DOI - 10.1002/adtp.201900160
Subject(s) - plga , hyaluronic acid , cd44 , pulmonary surfactant , drug delivery , chemistry , materials science , paclitaxel , nanoparticle , in vivo , docetaxel , targeted drug delivery , nanocarriers , nuclear chemistry , nanotechnology , cancer , in vitro , biochemistry , medicine , anatomy , microbiology and biotechnology , biology
Abstract Poly( d , l ‐lactide‐ co ‐glycolide) (PLGA)‐based nanotherapeutics are intensively employed for the treatment of various diseases, though they frequently suffer from stability, selectivity, and drug release problems. Here, a facile fabrication of coating‐sheddable CD44‐targeted PLGA nanoparticles using photoclick‐crosslinkable hyaluronic acid‐ graft ‐tetrazole (HA‐ g ‐Tet) as a surfactant followed by photoclick reaction with l ‐cystine dimethacrylamide (MA‐Cys‐MA) (X‐PHS@NPs) for targeted delivery of docetaxel (DTX) to breast tumors in vivo is reported. X‐PHS@NPs exhibit strong blue fluorescence and a size of 109 nm. DTX‐loaded X‐PHS@NPs (DTX‐X‐PHS@NPs), while stable at physiological conditions (pH 7.4, 37 °C), release about 76.6% DTX under 10 m glutathione conditions. DTX‐X‐PHS@NPs are potent toward CD44‐overexpressing MCF‐7 human breast cancer cells with a low IC 50 of 0.27 µg mL −1 . Interestingly, X‐PHS@NPs reveal excellent tumor penetration ability and DTX‐X‐PHS@NPs induce significantly more effective inhibition of MCF‐7 human breast tumors in nude mice than free DTX. These coating‐sheddable CD44‐targeted PLGA nanoparticles provide an interesting platform for cancer chemotherapy.