Premium
DNA Vaccine Mediated by Rambutan‐Like Mesoporous Silica Nanoparticles
Author(s) -
Song Hao,
Yang Yannan,
Tang Jie,
Gu Zhengying,
Wang Yue,
Zhang Min,
Yu Chengzhong
Publication year - 2020
Publication title -
advanced therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.125
0ISSN - 2366-3987
DOI - 10.1002/adtp.201900154
Subject(s) - dna vaccination , adjuvant , immune system , antigen , mesoporous silica , immunopotentiator , cd8 , biology , immunization , immunology , mesoporous material , biochemistry , catalysis
The development of safe and effective DNA vaccines is of great significance for treating various diseases. Mesoporous silica nanoparticles (MSNs) have been widely employed either for gene delivery or as adjuvants to amplify the immune responses, but rarely reported in DNA vaccines. In this study, the first report of MSNs‐based DNA vaccine by using rambutan‐like MSNs as both gene vector and adjuvant is presented. The high antigen expression and enhanced dendritic cell maturation generated by the MSNs‐based DNA vaccine lead to superior immune response. Boosted antigen‐specific IgG antibody, enhanced cytokine production of IFN‐γ, and amplified CD8 + T cells are observed for mice treated with MSNs‐based vaccines. This study showcases a powerful DNA vaccine platform with outstanding immune responses, which provides useful guidance for the design of effective nanomaterial‐based vaccines.