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Recent Advances in Particulate Adjuvants for Cancer Vaccination
Author(s) -
Song Cui,
Li Feng,
Wang Shuang,
Wang Jianghua,
Wei Wei,
Ma Guanghui
Publication year - 2020
Publication title -
advanced therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.125
0ISSN - 2366-3987
DOI - 10.1002/adtp.201900115
Subject(s) - vaccination , microvesicles , immune system , adjuvant , antigen , cancer , immunology , medicine , chemistry , microrna , biochemistry , gene
By activating/stimulating antigen‐presenting cells (APCs) and efficiently inducing humoral or cellular immune responses, particulate adjuvants have become one of the most ambitious and promising strategies in cancer vaccination. A large number of materials have been studied for their use as particulate adjuvants, including inorganic materials, polymeric materials, liposomes, emulsions, and exosomes. According to their unique physicochemical properties, these particulate adjuvants mainly work in three aspects: antigen delivery, APC activation, and antigen cross‐presentation, and they show great promise in various antitumor applications. This progress report highlights the recent advances in the study of particulate adjuvants, ranging from their materials, functions, and physicochemical properties to their applications in cancer vaccination.