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Harnessing CURATE.AI as a Digital Therapeutics Platform by Identifying N‐of‐1 Learning Trajectory Profiles
Author(s) -
Kee Theodore,
Weiyan Chee,
Blasiak Agata,
Wang Peter,
Chong Jordan K.,
Chen Jonna,
Yeo B. T. Thomas,
Ho Dean,
Asplund Christopher L.
Publication year - 2019
Publication title -
advanced therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.125
0ISSN - 2366-3987
DOI - 10.1002/adtp.201900023
Subject(s) - artificial intelligence , machine learning , training (meteorology) , computer science , trajectory , task (project management) , psychological intervention , medicine , engineering , physics , systems engineering , astronomy , psychiatry , meteorology
Conventional therapeutic interventions, which range from drug treatment to learning and training regimens, are often given at a fixed dose/intensity. This often leads to sub‐optimal responses, or even none at all. Similarly, fixed intensity training can lead to plateaus in learning trajectories and training outcomes. This barrier will impact the field of digital therapeutics, where drug‐based therapies may be complemented or replaced by learning and training platforms. A potential solution is to optimize training by identifying N‐of‐1 (single subject) training profiles that can then enhance learning trajectories through individualized training regimens. In this study, CURATE.AI, a mechanism‐independent and indication‐agnostic artificial intelligence (AI) platform, is used to identify N‐of‐1 learning trajectory profiles for healthy volunteers trained on the Multi‐Attribute Task Battery (MATB), a flight deck simulator developed by the National Aeronautics and Space Administration and United States Air Force. By leveraging modulated MATB training intensity in a prospective study, CURATE.AI successfully develops N‐of‐1 learning trajectory profiles that may actionably mediate training optimization on the single‐subject level, by dynamically identifying training inputs that drive the best possible scoring outcome. Therefore, CURATE.AI‐guided training may serve as a powerful optimization platform for digital therapy, student learning, cognitive decline prevention, and other indications.