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Multilayer Microcapsules: Ultrasound‐Triggered Delivery of Anticancer Therapeutics from MRI‐Visible Multilayer Microcapsules (Adv. Therap. 5/2018)
Author(s) -
Alford Aaron,
Rich Megan,
Kozlovskaya Veronika,
Chen Jun,
Sherwood Jennifer,
Bolding Mark,
Warram Jason,
Bao Yuping,
Kharlampieva Eugenia
Publication year - 2018
Publication title -
advanced therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.125
0ISSN - 2366-3987
DOI - 10.1002/adtp.201870018
Subject(s) - drug delivery , nanoparticle , ultrasound , nanotechnology , chemistry , drug carrier , mri contrast agent , materials science , biomedical engineering , medicine , radiology
In article number 1800051 , Jason Warram, Yuping Bao, Eugenia Kharlampieva and co‐workers demonstrate ultrasound‐triggered drug release from MRI‐visible polymeric microcapsules. Iron oxide nanoparticles are attached to the microcapsules which provide imaging contrast rivaling commercial contrast agents at a fraction of the metal concentration. The encapsulated drug is selectively released through ultrasound irradiation with minimized off‐target uptake.