Premium
Energy‐Coupling Factor Transporters as Novel Antimicrobial Targets
Author(s) -
Bousis Spyridon,
Setyawati Inda,
Diamanti Eleonora,
Slotboom Dirk J.,
Hirsch Anna K. H.
Publication year - 2019
Publication title -
advanced therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.125
0ISSN - 2366-3987
DOI - 10.1002/adtp.201800066
Subject(s) - druggability , antimicrobial , biology , virulence factor , drug discovery , computational biology , efflux , antibiotics , virulence , microbiology and biotechnology , bioinformatics , genetics , gene
In an attempt to find new antibiotics, novel ways of interfering with important biological functions should be explored, especially with those which are necessary or even irreplaceable for bacterial survival, growth, and virulence. The purpose of this review is to highlight B‐type vitamin transporters from the energy‐coupling factor (ECF) family, which are not present in humans, as potential antimicrobial targets. In addition, a druggability analysis of an ECF transporter for folic acid and sequence‐conservation studies in seven prominent pathogens revealed new druggable pockets. Evaluation of the presence of de novo biosynthetic routes for the vitamins in question in the seven pathogens confirmed that this target class holds promise for the discovery of antimicrobial drugs with a new mechanism of action, possibly on a broad‐spectrum level.