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Multifunctional Nanotherapeutics for Photothermal Combination Therapy of Cancer
Author(s) -
Tian Ye,
Guo Ranran,
Yang Wuli
Publication year - 2018
Publication title -
advanced therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.125
0ISSN - 2366-3987
DOI - 10.1002/adtp.201800049
Subject(s) - photothermal therapy , cancer therapy , combination therapy , cancer , nanotechnology , medicine , cancer treatment , pharmacology , materials science
Abstract Recently, photothermal therapy (PTT) has demonstrated excellent results in the treatment of preclinical cancer models and thus attracted intensive interests from the research fields of material science, biochemistry, oncology, and pharmacy. Also, its combination with other cancer therapies shows great promise for clinical application: PTT is able to make up for the drawbacks of others and improve the prognosis through various synergistic effects. In these combination therapies, design of nanoscale multifunctional therapeutics is key to achieve enhanced or even synergistic therapeutic effect. Herein, the recent progress is summarized in the development of strategies involving combination of PTT with other cancer therapies, conventional or emerging, with increased efficacy. The highlight lies in integrating various functional units to form multifunctional nanomaterials that play the role of photothermal agents as well as other therapeutics in a combination therapy and the design of an effective targeted delivery system for them. Smart combination of therapies will undoubtedly improve the therapeutic efficacy and make a contribution to the advancement in fighting cancer.