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Coating Nanoparticles with Gastric Epithelial Cell Membrane for Targeted Antibiotic Delivery against Helicobacter pylori Infection
Author(s) -
Angsantikul Pavimol,
Thamphiwatana Soracha,
Zhang Qiangzhe,
Spiekermann Kevin,
Zhuang Jia,
Fang Ronnie H.,
Gao Weiwei,
Obonyo Marygorret,
Zhang Liangfang
Publication year - 2018
Publication title -
advanced therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.125
0ISSN - 2366-3987
DOI - 10.1002/adtp.201800016
Subject(s) - nanocarriers , helicobacter pylori , microbiology and biotechnology , antibiotics , bacteria , drug delivery , pathogen , in vivo , clarithromycin , in vitro , bacterial cell structure , targeted drug delivery , chemistry , biology , nanotechnology , materials science , biochemistry , genetics
Inspired by the natural pathogen–host interactions and adhesion, this study reports on the development of a novel targeted nanotherapeutic for the treatment of Helicobacter pylori infection. Specifically, plasma membranes of gastric epithelial cells (e.g., AGS cells) are collected and coated onto antibiotic‐loaded polymeric cores; the resulting biomimetic nanoparticles (denoted AGS‐NPs) bear the same surface antigens as the source AGS cells and thus have inherent adhesion to H. pylori bacteria. When incubated with H. pylori bacteria in vitro, the AGS‐NPs preferentially accumulate on the bacterial surfaces. Using clarithromycin (CLR) as a model antibiotic and a mouse model of H. pylori infection, the CLR‐loaded AGS‐NPs demonstrate superior therapeutic efficacy when compared with the free drug counterpart as well as a non‐targeted nanoparticle control group. Overall, this work illustrates the promise and strength of using natural host cell membranes to functionalize drug nanocarriers for targeted drug delivery to pathogens that colonize on the host cells. As host–pathogen adhesion represents a common biological event for various types of pathogenic bacteria, the bioinspired nanotherapeutic strategy reported here represents a versatile delivery platform that may be applied to treat numerous infectious diseases.