Premium
Front Cover Picture: Palladium‐Catalyzed Regioselective C−H Arylation of 4‐Azaindazole at C3, C5 and C7 Positions (Adv. Synth. Catal. 16/2021)
Author(s) -
Faarasse Soukaina,
El Kazzouli Saïd,
Bourzikat Otmane,
Bourg Stéphane,
AciSèche Samia,
Bonnet Pascal,
Suzenet Franck,
Guillaumet Gérald
Publication year - 2021
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.202100859
Subject(s) - chemistry , palladium , regioselectivity , catalysis , front cover , ligand (biochemistry) , medicinal chemistry , toluene , phosphine oxide , stereochemistry , phosphine , cover (algebra) , organic chemistry , receptor , mechanical engineering , engineering , biochemistry
The front cover picture , designed by El Kazzouli and co‐workers, illustrates the site‐selective C5 and C7 palladium‐catalyzed C‐H arylations of 4‐azaindazole N ‐oxide. The 1,10‐phenanthroline as ligand and Pd(OAc) 2 as catalyst in toluene promoted the activation of C5 position, while the triphenyl phosphine as ligand and PdCl 2 as catalyst in DMA directed the arylation at C7 position. This new method allows the synthesis of C5, C7‐diarylated 4‐azaindazole N ‐oxides as well as the C3, C5, C7‐triarylated 4‐azaindazoles. Details can be found in the Communication by El Kazzouli, Suzenet, Guillaumet and co‐workers (S. Faarasse, S. El Kazzouli, O. Bourzikat, S. Bourg, S. Aci‐Sèche, P. Bonnet, F. Suzenet, G. Guillaumet Adv. Synth. Catal . 2021 , 363 , 3937–3945; DOI: 10.1002/adsc.202001421).