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Visible Light‐Mediated Synthesis of Se−S Bond‐Containing Peptides
Author(s) -
Lapcinska Sindija,
Dimitrijevs Pavels,
Arsenyan Pavel
Publication year - 2021
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.202100751
Subject(s) - chemistry , linker , biocompatible material , peptide bond , sulfur , combinatorial chemistry , visible spectrum , amino acid , photochemistry , organic chemistry , biochemistry , medicine , physics , optoelectronics , computer science , biomedical engineering , operating system
Abstract A visible light‐initiated method has been developed for preparation of Se−S bond‐containing peptides. The method is based on generation of sulfur‐centered radical employing organic dye. The protocol is tolerant to unprotected peptides with “sensitive” amino acids. The stability of Se−S bond is evaluated in buffers at different pH (3.0–10.0) and also in the presence of oxidants and reducing agents. Additionally, the ability of Se−S bond to serve as an oxidation sensitive linker in biocompatible materials has been confirmed.