Multicomponent Catalytic Enantioselective Synthesis of Isoxazolidin‐5‐Ones | Zendy

Annibaletto Julien | Zendy; Martzel Thomas | Zendy; Levacher Vincent | Zendy; Oudeyer Sylvain | Zendy; Brière JeanFrançois | Zendy

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Multicomponent Catalytic Enantioselective Synthesis of Isoxazolidin‐5‐Ones

Author(s) -

Annibaletto Julien,

Martzel Thomas,

Levacher Vincent,

Oudeyer Sylvain,

Brière JeanFrançois

Publication year - 2021

Publication title -

advanced synthesis and catalysis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.541

H-Index - 155

eISSN - 1615-4169

pISSN - 1615-4150

DOI - 10.1002/adsc.202100719

Subject(s) - enantioselective synthesis , moiety , amide , bifunctional , steric effects , catalysis , chemistry , combinatorial chemistry , hydroxamic acid , organic chemistry , stereochemistry

We report herein a strategy to afford a multicomponent catalytic enantioselective synthesis of β‐substituted isoxazolidin‐5‐ones via a KMC process promoted by a suited cupreine used as bifunctional organocatalyst. The hydroxamic acid component, with a sterically hindered amide moiety, proved to be key for the successful formation and transformation of the obtained original N ‐amide isoxazolidin‐5‐ones.

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