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Multicomponent Catalytic Enantioselective Synthesis of Isoxazolidin‐5‐Ones
Author(s) -
Annibaletto Julien,
Martzel Thomas,
Levacher Vincent,
Oudeyer Sylvain,
Brière JeanFrançois
Publication year - 2021
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.202100719
Subject(s) - enantioselective synthesis , moiety , amide , bifunctional , steric effects , catalysis , chemistry , combinatorial chemistry , hydroxamic acid , organic chemistry , stereochemistry
We report herein a strategy to afford a multicomponent catalytic enantioselective synthesis of β‐substituted isoxazolidin‐5‐ones via a KMC process promoted by a suited cupreine used as bifunctional organocatalyst. The hydroxamic acid component, with a sterically hindered amide moiety, proved to be key for the successful formation and transformation of the obtained original N ‐amide isoxazolidin‐5‐ones.