Ir(III)‐Catalyzed and Ag 2 O‐Promoted C−H/C−H Cross‐Coupling/Intramolecular Cyclization of Ketene Dithioacetals with Benzothiophene | Zendy

Chen Jinkang | Zendy; Yin Chuanliu | Zendy; Zhou Jian | Zendy; Yu Chuanming | Zendy

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Ir(III)‐Catalyzed and Ag 2 O‐Promoted C−H/C−H Cross‐Coupling/Intramolecular Cyclization of Ketene Dithioacetals with Benzothiophene

Author(s) -

Chen Jinkang,

Yin Chuanliu,

Zhou Jian,

Yu Chuanming

Publication year - 2021

Publication title -

advanced synthesis and catalysis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.541

H-Index - 155

eISSN - 1615-4169

pISSN - 1615-4150

DOI - 10.1002/adsc.202100682

Subject(s) - benzothiophene , chemistry , ketene , intramolecular force , tandem , catalysis , functional group , sulfur , medicinal chemistry , stereochemistry , intramolecular reaction , photochemistry , organic chemistry , thiophene , materials science , composite material , polymer

A tandem Ir(III)‐catalyzed and Ag 2 O‐promoted cross‐dehydrogenative coupling (CDC)/ intramolecular cyclization of ketene dithioacetals with benzothiophene derivatives was developed, affording a series of sulfur‐containing cyclization compounds. Mechanistic investigation demonstrated a radical process may be involving intramolecular cyclization. This tandem reaction described herein could be carried out with a broad range of substrates and wide functional group tolerance.

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