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Copper‐Catalyzed One‐Pot Cascade Cyclization for the Synthesis of Isoindolo[2,1‐ a ]quinoxalines
Author(s) -
Li Ling,
Liu ZhenTing,
Hu XiangPing
Publication year - 2021
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.202100643
Subject(s) - chemistry , propargyl , cascade , catalysis , copper , combinatorial chemistry , substrate (aquarium) , organic chemistry , chromatography , geology , oceanography
A copper‐catalyzed one‐pot cascade cyclization of 2‐(1‐(acetyloxy)propargyl)benzaldehydes with o ‐phenylenediamines for an access to substituted isoindolo[2,1‐ a ]quinoxalines has been developed. The reaction features readily available starting materials, simple operational procedure, and broad substrate scopes. Under optimal conditions, various isoindolo[2,1‐ a ]quinoxalines were afforded in 41–88% yields.
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