Premium
Phosphine‐Free Manganese(II)‐Catalyst Enables Acceptorless Dehydrogenative Coupling of Alcohols with Indoles
Author(s) -
Yadav Vinita,
Balaraman Ekambaram,
Mhaske Santosh B.
Publication year - 2021
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.202100621
Subject(s) - chemistry , moiety , catalysis , manganese , combinatorial chemistry , pincer movement , phosphine , ligand (biochemistry) , indole test , organic chemistry , biochemistry , receptor
Herein, an air‐stable, molecularly defined NNN−Mn(II) pincer complex catalyzed acceptorless dehydrogenative coupling of alcohols with indoles is reported. A wide variety of symmetrical and unsymmetrical bis(indolyl)methane derivatives as well as some structurally important products such as Vibrindole A, Turbomycin B alkaloid, Antileukemic, and Anticancer agents were synthesized. Mechanistic studies illustrate the importance of the NH moiety in the complex and the crucial role of metal‐ligand cooperation during catalysis.