B(C 6 F 5 ) 3 ‐Catalyzed Hydroarylation of Terminal Alkynes with Phenols | Zendy

Zhou Jiaming | Zendy; Huang Jin | Zendy; Lu Changhui | Zendy; Jiang Huanfeng | Zendy; Huang Liangbin | Zendy

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B(C 6 F 5 ) 3 ‐Catalyzed Hydroarylation of Terminal Alkynes with Phenols

Author(s) -

Zhou Jiaming,

Huang Jin,

Lu Changhui,

Jiang Huanfeng,

Huang Liangbin

Publication year - 2021

Publication title -

advanced synthesis and catalysis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.541

H-Index - 155

eISSN - 1615-4169

pISSN - 1615-4150

DOI - 10.1002/adsc.202100590

Subject(s) - chemistry , protonation , phenols , catalysis , substrate (aquarium) , alkyne , phenol , terminal (telecommunication) , medicinal chemistry , stereochemistry , organic chemistry , ion , telecommunications , oceanography , computer science , geology

We developed a B(C 6 F 5 ) 3 catalyzed hydroarylation of terminal alkynes with various phenols at room temperature without adding any additives, leading to the synthesis of 2‐ gem ‐vinylphenols with good regio‐selectivity. Those transformations featured a broad substrate scope with moderate yields. Mechanism studies indicated that those transformations proceeded through the activation of phenol by B(C 6 F 5 ) 3 with subsequent protonation of alkyne/Friedel‐Crafts‐type reaction.

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