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Recent Advances in Cobalt‐Catalyzed, Directing‐Group‐Assisted C−H Bond Amidation Reactions
Author(s) -
Sunny Sereena,
Karvembu Ramasamy
Publication year - 2021
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.202100558
Subject(s) - chemistry , amination , cobalt , catalysis , group (periodic table) , combinatorial chemistry , functional group , molecule , transition metal , atom economy , organic synthesis , nanotechnology , organic chemistry , polymer , materials science
C−N bond formation reactions have garnered a lot of interest in recent years due to the predominance of nitrogen‐containing compounds in most pharmacological medications. Since traditional approaches have several limitations, the transition metal‐catalyzed C−H amidation/amination process has arisen as a more atom‐friendly option. Because there are so many distinct kinds of C−H bonds in organic molecules, selective amidation of C−H bonds has always been a challenge. In this scenario, the directing‐group‐assisted C−H amidation has received considerable attention, especially with inexpensive metal cobalt, due to its unique properties and efficiency. We summarize recent developments in cobalt‐catalyzed directing‐group‐aided C−H bond amidation reactions in this review. We briefly discuss the evolution of directing group preferences and their function in the site selection.