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An Amphiphilic (salen)Co Complex – Utilizing Hydrophobic Interactions to Enhance the Efficiency of a Cooperative Catalyst
Author(s) -
SolísMuñana Pablo,
Salam Joanne,
Ren Chloe Z.J.,
Carr Bronte,
Whitten Andrew E.,
Warr Gregory G.,
Chen Jack L.Y.
Publication year - 2021
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.202100494
Subject(s) - chemistry , amphiphile , catalysis , kinetic resolution , cooperativity , homogeneous , hydrophobic effect , hydrolysis , combinatorial chemistry , chemical engineering , organic chemistry , copolymer , enantioselective synthesis , thermodynamics , polymer , biochemistry , physics , engineering
An amphiphilic (salen)Co(III) complex is presented that accelerates the hydrolytic kinetic resolution (HKR) of epoxides almost 10 times faster than catalysts from commercially available sources. This was achieved by introducing hydrophobic chains that increase the rate of reaction in one of two ways – by enhancing cooperativity under homogeneous conditions, and increasing the interfacial area under biphasic reaction conditions. While numerous strategies have been employed to increase the efficiency of cooperative catalysts, the utilization of hydrophobic interactions is scarce. With the recent upsurge in green chemistry methods that conduct reactions ‘on water’ and at the oil‐water interface, the introduction of hydrophobic interactions has potential to become a general strategy for enhancing the catalytic efficiency of cooperative catalytic systems.