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State of the Art in Crystallization‐Induced Diastereomer Transformations
Author(s) -
Kolarovič Andrej,
Jakubec Pavol
Publication year - 2021
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.202100473
Subject(s) - diastereomer , chemistry , crystallization , filtration (mathematics) , combinatorial chemistry , stereochemistry , organic chemistry , pure mathematics , mathematics
Crystallization‐induced diastereomer transformations (CIDT) enable isolation of the target compounds in high enantio‐ and diastereomeric purities and with up to quantitative yields simply by filtration. Numerous inspiring examples of this appealing synthetic strategy reported over the last fifteen years are reviewed. Important observations along with aspects to consider when designing CIDT experiments are discussed.