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Stereoselective Synthesis of Enantiopure Oxazolidinones via Biocatalytic Asymmetric Aminohydroxylation of Alkenes
Author(s) -
Zhou XiaoYing,
Wan NanWei,
Li YingNa,
Ma Ran,
Cui BaoDong,
Han WenYong,
Chen YongZheng
Publication year - 2021
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.202100468
Subject(s) - enantiopure drug , chemistry , regioselectivity , stereoselectivity , combinatorial chemistry , biocatalysis , organic chemistry , enantioselective synthesis , catalysis , reaction mechanism
Chiral oxazolidinones are of significance in both medicinal and synthetic chemistry, while preparing these compounds usually involves using expensive starting materials and harsh reaction conditions. Herein, a one‐pot biocatalytic cascade process was developed for stereo‐ and regioselective aminohydroxylation of diverse alkenes by combining styrene monooxygenase and halohydrin dehalogenase, providing an approach to enantiopure oxazolidinones.