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Iron‐Catalyzed Three‐Component Cyanoalkylsulfonylation of 2,3‐Allenoic Acids, Sulfur Dioxide, and Cycloketone Oxime Esters: Access to Cyanoalkylsulfonylated Butenolides
Author(s) -
Zheng Xiangyun,
Zhong Tianshuo,
Yi Xiao,
Shen Qitao,
Yin Chuanliu,
Zhang Lei,
Zhou Jian,
Chen Junyu,
Yu Chuanming
Publication year - 2021
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.202100463
Subject(s) - chemistry , oxime , tandem , catalysis , component (thermodynamics) , ring (chemistry) , sulfur dioxide , cyclobutanone , sulfur , organic chemistry , medicinal chemistry , materials science , physics , composite material , thermodynamics
An iron‐catalyzed three‐component cyanoalkylsulfonylation of 2,3‐allenoic acids, K 2 S 2 O 5 , and the ring‐opening of cyclobutanone oxime esters is described. The radical tandem cyclization route allows access to diverse cyanoalkylsulfonylated butenolides in moderate to good yields under mild conditions. Moreover, the products are further converted, offering the corresponding derivatives.