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Review on Asymmetric Catalysis Employing 5 H‐ Oxazol‐4‐Ones as α‐Hydroxy Carboxylic Acid Surrogates
Author(s) -
Jain Anshul,
Rairmal K.
Publication year - 2021
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.202100456
Subject(s) - synthon , chemistry , nucleophile , catalysis , organic synthesis , alkyl , organic chemistry , enantioselective synthesis , carboxylic acid , combinatorial chemistry , organocatalysis
Heterocycles play an essential role in medicinal as well as in organic synthetic chemistry. The synthesis of these valuable scaffolds is an emerging and challenging field of today‘s research in organic chemistry. In recent years, several heterocycles as new synthons have emerged as potential nucleophiles in asymmetric transformations. Among them, 5 H ‐oxazol‐4‐one is one of the strategic synthons for synthesizing enantioenriched α‐alkyl‐α‐hydroxycarboxylic acid derivatives, which are otherwise very challenging via direct installation of a hydroxy group at the α‐position of carbonyls. Over the years, considerable progress has been made to establish new and efficient methodologies under mild reaction conditions exploiting metal‐ and organo‐catalysis. This review presents a comprehensive summary of various catalytic development in asymmetric synthesis employing 5 H ‐oxazol‐4‐ones as α‐alkyl‐α‐hydroxycarboxylic acid surrogates.