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Visible‐Light‐Mediated Aerobic Oxidative C( sp 3 )−C( sp 3 ) Bond Cleavage of Morpholine Derivatives Using 4CzIPN as a Photocatalyst
Author(s) -
Dong ChunLin,
Huang LanQian,
Guan Zhi,
Huang ChuSheng,
He YanHong
Publication year - 2021
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.202100455
Subject(s) - chemistry , morpholine , oxidative cleavage , bond cleavage , photochemistry , cleavage (geology) , selectivity , visible spectrum , oxidative phosphorylation , metal , medicinal chemistry , stereochemistry , organic chemistry , catalysis , biochemistry , physics , geotechnical engineering , optoelectronics , fracture (geology) , engineering
Herein, a metal‐free strategy for the aerobic oxidative cleavage of the inert C( sp 3 )−C( sp 3 ) bond was developed. Deconstruction of morpholine derivatives was conducted using visible light as an energy source and O 2 as an oxidant under mild conditions. This procedure demonstrated suitable selectivity and functional group tolerance. Moreover, a possible mechanism involving a radical process was proposed based on a series of mechanism exploration and control experiments.